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Organisme : Instituts de recherche en santé du Canada |
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Projets financés à l'Université Laval |
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A 2x2 factorial randomized controlled trial to elucidate how ultra-processed foods modulate cardiometabolic risk
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Addressing stigmatization of Indigenous patients: Co-developing structural and educational strategies through a nuanced understanding of cultural risk in the Quebec healthcare system
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Adrenergic control of liver metabolism in obesity and diabetes
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A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies
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Air pollution, climate and COPD: acute and long-term impacts in Canadian populations
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Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders
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Améliorer la prédiction du risque cardiovasculaire en considérant les stresseurs psychosociaux au travail
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Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies
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Anatomically relevant brachytherapy implants by a 3D printing and radiosenstizing approach
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A non-restrictive approach to facilitate appetite control and long-term body weight loss in individuals with obesity: can we do better?
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Anti-Thrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (ATTACC-CAP)
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Apnea, sex and FMO: Are flavin-containing monooxygenases the new anti-ox that prevent metabolic disorders under intermittent hypoxia?
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A Pre-Clinical Research for Treatment of Prematurity and BronchoPulmonary Dysplasia through Intracrinology
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A Randomized Trial of Partial Breast Irradiation
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A Randomized Trial of Regional Radiotherapy in Luminal A Breast Cancer
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A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease
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A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living with HIV
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ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension
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Autoantibodies and antibody-producing cells in neurological autoimmune diseases: from biology to therapeutic targeting
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Biochemical and structural studies of poly-TPR containing proteins involved in epigenetic signalling
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Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia
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Blocking the Effects of Serotonin to Prevent Ischemic Mitral Regurgitation: a Randomized Trial
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Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
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BRAINapt: TBI International Adaptive Platform Trial
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Brain magnetic stimulation to reduce levodopa-induced dyskinesias in Parkinson’s disease
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Causes and consequences of anti-PEG antibodies
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Cellular characterization of a novel putative immune biomarker of MS progression
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Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays.
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Characterizing and monitoring the healthfulness of the food supply: a fundamental step towards creating healthier food environments
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Comparative effectiveness of opioid versus opioid-free post-discharge analgesia after outpatient breast surgery: A randomized controlled trial
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COMPLETE-2: A prospective, randomized, multi-centre trial of physiology-guided versus angiography-guided complete revascularization to treat multivessel
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Complex genetics of hypertrophic cardiomyopathy: Towards an integration of polygenic risk in clinical care
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Computational neuroscience modelling of cognitively healthy aging and Alzheimer's disease
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Control of metabolic inflammaging by traffic of B lymphocytes in adipose tissues
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Deafnesses: Reconfiguring expertise and reconsidering sensory experiences with/out the cochlear implant
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Deciphering cellular modulators of the microRNA pathway
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Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
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Deciphering the role of antiviral innate immune mechanisms among respiratory viruses
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Deciphering the role of the Yin Yang1 (YY1) transcription factor to understand pleuropulmonary blastoma
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Defining the global transcriptional response to perturbations
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Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models
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De la perte de contrôle alimentaire au trouble d'accès hyperphagique: trajectoires évolutives et facteurs de risque.
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Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders
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Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models
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Dérivation et validation d'un outil de stratification du risque applicable en préhospitalier et visant à identifier les personnes âgées nécessitant des soins urgents ou une hospitalisation à la suite d’une chute
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Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia
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Development of statistical methods for estimating optimal adaptive treatment strategies with survival outcomes
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Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease
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Dissecting the cortico-striatal and tegmental pathways’ contribution to stress response
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Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures
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Dysregulation of TET2 and DNMT3A promotes pulmonary arterial hypertension (PAH) through inflammation : A new mechanism of PAH
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Early markers of cardiovascular disease and lifestyle habits in youth with type 1 diabetes followed to young adulthood
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Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE)
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Effects of an Open Lung protective protective EXTubation strategy compared to a conventional extubation strategy on postoperative pulmonary complications after general anesthesia as part of a comprehensive lung protective ventilation ...
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Elucidating patient and healthcare practitioner decision-making about chemotherapy-induced peripheral neuropathy-related
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Elucidating the role of the IL-1 system in the pathogenesis of CNS autoimmunity
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Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury
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Elucidation of bromodomain functions within SWI/SNF complexes
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Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy
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Engineering a vascularized macroencapsulation device for diabetes cellular therapy
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Engineering bioactive dressings from mesenchymal cells to enhance healing of irradiated skin wounds
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Enhancing speech perception in noise in healthy older adults and in older adults with cognitive impairment using non-invasive brain stimulation
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Epigenome wide study for the investigation of DNA methylation as therapeutic target and novel biomarker of pulmonary arterial hypertension
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Étude de l'éco-efficience du port de l'équipement de protection individuelle contre la COVID-19 dans les urgences pour un contexte post-pandémique
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Evaluating and facilitating the implementation of stepped and measurement-based mental health care in Family Medicine Groups
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Evaluating the ongoing impact of COVID-19 on youth substance use and mental health trajectories over time: renewal of the COMPASS prospective cohort.
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Évaluation de l'acceptabilité d'un Programme de 1re Ligne d'Interventions en Ergothérapie pour le Rétablissement et le Retour au travail des personnes ayant un Trouble Mental Courant (P1LIERR-TMC)
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Exploring the biology of the hepatokine TSK in health and disease.
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Exploring the Interplay between Metabolic and Epigenetic Signalling Pathways to Regulate Neointima Hyperplasia
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Exploring the role of phosphoinositides in the trafficking of proteins to the apical complex in the malaria parasite Plasmodium falciparum
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Exploring the role of phosphoinositides in the trafficking of proteins to the apical complex in the malaria parasite Plasmodium falciparum.
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Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population
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Fatty acid metabolism in carriers of apolipoprotein E. epsilon 4 allele: determining the blood-to-brain link
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Favoriser l'engagement des femmes ayant eu un cancer du sein dans les décisions concernant l'hormonothérapie adjuvante prolongée
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FGF-21 in Alzheimer's disease
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Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
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Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability
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Functional dissection of the serotoninergic system in normal and pathological conditions
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Function and neuroprotective potential of new target genes against Parkinson's disease
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Genetic dissection of propriospinal interneuronal pathways and their reticulospinal inputs pertaining to locomotor control and recovery after spinal cord injury
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Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers
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Gentrification des soins de première ligne au Québec : une étude longitudinale multiméthode
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Global signals in dendrites of GABAergic inhibitory interneurons : mechanisms and function
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Histaminergic Neuronal Mechanisms Regulating Feeding
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Host iNOS dictates gut dysbiosis, bacterial translocation and tissue insulin resistance in murine and human obesity
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How does insulin interact with the blood-brain barrier? Therapeutic implications for diabetes and Alzheimer’s disease
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Human herpesvirus 6 and chromosomal integration
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Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice
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Identification of innate immune pathways as targets for immunomodulatory therapy in herpes simplex virus encephalitis
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Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy
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Identifying the biological basis of GWAS hits for plasma triglyceride response to an omega-3 fatty acid supplementation
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Imaging Substudy of the BEST Trial: Balloon-Expandable versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis
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IMPACT, a supervised rehabilitation program for spastic ataxias: A rater-blinded, randomized controlled trial
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Impact of an Angiotensin Receptor Blocker in Aortic Stenosis - a Randomized Controlled Trial
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Improving mental health pratices recovering from traumatic injuries: Identifying prioritiez based on knowledge to practice gaps and interested parties needs and preferences
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Improving the quality of Canadian pediatric injury care: identifying priorities based on evidence, practice variations and stakeholder needs and preferences
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Improving vulnerable preschoolers' mental health: A superiority trial assessing the How-to Parenting Program
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Influence of Dopamine on Motor Learning and Stroke Recovery
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Integrating Multi-Omics, Multi-Modal Neuroimaging and Artificial intelligence for Biologically-defined Staging and Statification in the Alzheimer's Disease spectrum
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Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract
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Investigate the mechanisms regulating the fibrotic reaction mediated by perivascular cells in cerebrovascular disorders
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Investigating mechanisms of altered lipid metabolism in amyotrophic lateral sclerosis (ALS)
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Is a 12-week intervention involving multimodal physiotherapy, photobiomodulation or a combination of multimodal physiotherapy and photobiomodulation more effective than sham photobiomodulation for the reduction of pain among those with...
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Is a stepped model of care cost-effective compared to usual care for chronic musculoskeletal disorders? A randomized controlled trial
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Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia
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L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1
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La modulation des ganglions de la base par les afférences neurochimiques du tronc cérébral : implication dans la physiopathologie des troubles du mouvement
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La neuroplasticité du noyau subthalamique et de ses afférences en provenance du tronc cérébral: Implications dans la physiopathologie de la maladie de Parkinson
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Le bon soin au bon patient, au bon moment mais avec quelle modalité? Préférences des médecins omnipraticiens et des patients (fiche enfant - Gestion éthique)
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Le bon soin au bon patient, au bon moment mais avec quelle modalité? Préférences des médecins omnipraticiens et des patients (Fiche Parent pour Transferts inter et institutionnels)
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LEFT HF: LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
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Les conduites paternelles et la transmission intergénérationnelle des problèmes de santé mentale : une étude de cohorte père-mère-enfant débutant à la période prénatale
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Linking neonatal stress and anomalies of immune development in rats: novel insights into the origin of sex-based differences in viral infection severity
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Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery
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Mechanism of Ribosomal RNA Gene Silencing and Its Roles in Pluripotency and Cancer
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Mechanisms of action of sex-specific endocrine treatments in complementary models of Parkinson's disease
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Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1
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Mechanisms regulating contribution of pericytes to brain repair after stroke
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Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure for Older Patients with Cryptogenic Stroke and Patent Foramen Ovale: A Randomized Trial Research Proposal
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Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases
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Microglia as a viral reservoir for HIV-1 in the human brain and its role in neuroinflammation
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Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies
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Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability
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Modulation of cortical excitability with transcranial direct current stimulation: toward prevention of trauma-induced neocortical epileptogenesis
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Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse
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Molecular characterization of newly identified silicon transporters in animals
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Multi-Centre Cluster-Randomized Implementation of Canadian Syncope Pathway for Emergency Department Syncope Management
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Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair
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Multi-pathway cholesterol depletion on top of FOLFIRINOX in newly diagnosed metastatic pancreatic adenocarcinoma: a feasibility and proof-of-concept study
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Neurodevelopmental vs. Neurodegenerative: A study of neurodevelopmental consequences of FTD genetic mutations in at-risk youth
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Neurovascular adaptations driving stress-induced depression vs resilience
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Noradrenergic modulation of mouse cortical interneurons during sensorimotor learning
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Nutrient sensing mechanisms underlying the metabolic effects of dietary proteins in obesity and type 2 diabetes
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Obstructive Sleep Apnea and Long-Term Health Consequences
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Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues
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Optical Nanoscopy of cytoskeletal and synaptic remodeling in neurons
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Optimizing HPV vaccination programs in Low- and Middle-Income Countries (LMIC) and Canada to reduce inequalities and reach global elimination of cervical cancer: An integrated knowledge translation dynamic-modeling approach
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Optimizing HPV vaccination programs in Low- and Middle-Income Countries (LMIC) and High-Income Countries (HIC) to reduce inequalities and reach global elimination of cervical cancer: An integrated knowledge translation dynamic-modeling
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Optimizing patient adherence to stroke rehabilitation treatment: a telerehabilitation trial
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Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne
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Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model
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PARP inhibition in PAH: A Phase 1 clinical trial
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Periacetabular Osteotomy with or without arthroscopic management in patients with hip dysplasia: A multicenter randomized controlled trial
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Personal Social Networks, Built Environment and Cardiometabolic Risk Factors: a Prospective Investigation with Young Adults
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Phase II study to assess the safety of non-operative management (NOM) for low rectal cancer (LRC)
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Pilot study of a community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast
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Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis
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Potentiel thérapeutique des protectines contre les infections grippales
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Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS)
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Pre-clinical pharmacokinetic and efficacy assays with an efficient 17beta-hydroxysteroid dehydrogenase type 7 inhibitor for breast cancer therapy
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Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease
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Predicting Psychotic Relapse using Speech-based Early-detection
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Predicting weight loss and metabolic improvements after bariatric surgery through a novel genetic and epigenetic score
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Prévenir l’hypertension, le diabète de type 2 et les maladies cardiovasculaires en ciblant les stresseurs psychosociaux au travail, les longues heures de travail et les mauvaises habitudes de vie : Des fractions
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Preventing pathological protein spread in Huntington's disease: relevance to pathology and treatment
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Prévention du cancer du col de l’utérus en Côte d’Ivoire, Afrique de l’Ouest : Évaluation de l’efficacité du vaccin quadrivalent
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Priming MUC-16 positive ovarian and pancreatic cancer cells for immunotherapy using an alpha particle labeled radioimmunoconjugate
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Promoting healthy eating in early pregnancy in women at risk of gestational diabetes mellitus : does it improve glucose homeostasis ?
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Promoting healthy eating in early pregnancy in women at risk of gestational diabetes mellitus: does it improve glucose homeostasis?
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Prospective Evaluation of Breast-Conserving Surgery Alone in Low Risk Ductal Carcinoma in Situ Defined by a Molecular Expression Assay Combined with Clinico-Pathological Features
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Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer
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Real World Clinical and Economic Burden of Severe Burn Injuries
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Real-World Evaluation of the Efficacy, Safety and Cost-Effectiveness of Statins for Primary Prevention of Cardiovascular Disease Among the Elderly – A Causal Perspective to Treatment Trajectory Analysis
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Redéfinir la neuro-imagerie pour les patients âgés /adultes souffrant de traumatisme cranio-cérébral léger
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Reducing low-value practices in acute trauma care: a pragmatic cluster randomized controlled trial
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Régénération de la peau humaine : Une peau reconstruite par génie tissulaire pigmentée produite plus rapidement pour traiter les patients grands brûlés
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Réparation des lésions des nerfs périphériques par génie tissulaire
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Risk stratification and personalized therapy in lupus pregnancies
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Role and regulation of EPB41L5 in cancer-promoting cellular processes
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Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt
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Role of inflammation in recovery after spinal cord injury
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Role of megakaryocytes in Systemic Lupus Erythematosus
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Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease
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Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias
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Selective neuroimaging for head-injured emergency patients who take anticoagulant medication.
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Sex and Gender in Digital Health
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Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea.
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Sex-specific role of pericytes in stress-induced neurovascular changes underlying depression pathogenesis and treatment response
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Sleep and Circadian Misalignment and their Relation to Cardiometabolic Health during Adolescence
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Soulager la douleur chronique chez les aînés à l'aide de la stimulation transcrânienne par courant direct
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Strategies for the management of Atrial Fibrillation in patiEnts receiving HemoDialysis (SAFE-HD)
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Stress and loss of ovarian function: novel insights into the origins and treatment of respiratory control disorders in females
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Stress Hydrocortisone in Pediatric Septic Shock (The SHIPSS trial)
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Surveillance of Complex Renal Cysts: The SOCRATIC study
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Targeting Hypusine signaling: an opportunity to counter pulmonary vascular remodelling in pulmonary arterial hypertension
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Targeting Integrin Signaling to Alleviate Remodeling in Pulmonary Arteries and the Right Ventricle in Pulmonary Hypertension
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Targeting Mitosis and Senescence to Reverse Pulmonary Hypertension: A Promising Therapeutic Strategy
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Targeting mRNA translation to effectively treat uveal melanoma
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Targeting sex steroids to improve the response to bladder cancer immunotherapy
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Testosterone on airway hyperresponsiveness in asthma
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The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel
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The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation
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The Canadian CABG or PCI in Patients with Ischemic Cardiomyopathy (STICH 3.0) Trial
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The Canadian Severe Acute Respiratory Infection, Prospective, Perpetual Observational Study: Informing Clinical Care and the Public Health Response
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The impact of Monte Carlo dose calculations on prostate and breast low-dose rate brachytherapy dose-outcome relationships and radiobiological modeling
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The impact of the in utero environment on the developing human brain: Longitudinal investigations on epigenetic mechanisms in monozygotic twins from birth to adolescence
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The implication of PlGF in cutaneous fibrosis
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The interplay of sex hormones and chromosomes dictates pathogenicity in progressive CNS autoimmunity
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The molecular and functional impact of stress in the medial prefrontal cortex
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Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques
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Therapeutic Plasma Exchange in Septic Shock (PLEXSIS): A Pilot Study
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The Ribosomal RNA Genes in Growth, Pluripotency, Senescence and Cancer
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The right care, for the right patient, at the right time, by the right provider: A value-based comparison of the management of ambulatory respiratory diseases in walk-in clinics, primary care physician practices and emergency departments
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The role of chronic stress reactivity in the persistence of insomnia over time
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The test-negative design for the estimation of COVID-19 vaccine effectiveness: design evaluation and development of statistical methods in the evolving context
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The UGT to GUS equilibrium as novel target for the treatment of cholestatic autoimmune liver diseases
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Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes
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Toward a paradigm shift in the promotion of healthy eating: Systematic development and feasibility testing of an intervention
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Towards a comprehensive model of Spindle Assembly Checkpoint silencing
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Towards Personalized Dosimetry-Based Radioligand Therapy of Prostate Cancer as a New Standard of Practice
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Training Intervention and Program of Support (TIPS) for fostering the adoption of family-centred telehealth interventions in pediatric rehabilitation: A pan-Canadian implementation-effectiveness study
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Trajectories of Externalizing Behaviour Problems and New Parents’ Distress and Harsh Parenting: A Genetically-Informed, Prospective Longitudinal Study
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Transitioning patients with advanced chronic kidney disease to home or facility dialysis: understanding the experience and quality of life for patients and their caregivers (TRANSIT-CARE)
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Understanding Delirium Pathophysiology using Urine Metabolomics from Older People with Hip Fractures
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Understanding mitochondrial metabolism to identify prostate cancer metabolic vulnerabilities
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Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing.
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Un nouveau vecteur de médicaments ophtalmiques à base de nanoparticules d'or
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Unraveling the functional domains of a novel pluripotency-associated lncRNA
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Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus
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Unraveling the role Motile and Immotile Primary Cilia in Efferent Ductule Homeostasis and Male Fertility
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Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach
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Unravelling the role of ARHGEF3 during skin development and hair follicle regeneration
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Unravelling the role of primary cilia in prostate cancer initiation and progression
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Urethral reconstruction using tissue engineering, final steps towards clinical translation
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Usage d'analgésiques en conditions réelles de pratique chez les personnes vivant avec de la douleur chronique : Une approche novatrice de modélisation de la polypharmacie sous forme de trajectoires de risque
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Usage du cannabis et ses effets sur le déroulement et l'issue de la grossesse, la santé et le développement de l'enfant d'âge préscolaire
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Validation et raffinement prospectif multicentrique des Quebec Brain Injury Categories pour les patients ayant subi un
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